Bio

Metabolism, Diet, and Precision Therapeutic Response in Human Health

The Liu Group develops and applies advanced metabolomics approaches to understand how diet, environment, and lifestyle interact with metabolism to influence disease and therapeutic response. A central focus is elucidating how nutritional and metabolic states regulate cancer cell sensitivity to targeted therapies, with the goal of enabling more precise treatment strategies that integrate drugs, diet, and patient-specific metabolic features.The group also investigates how endogenous metabolic toxins, shaped by diet and lifestyle, contribute to cellular damage and disease risk. Using high-resolution mass spectrometry–based metabolomics, the group quantitatively profiles hundreds of metabolites and lipids to uncover molecular mechanisms linking metabolism to health outcomes. These efforts are supported by integrated biochemical, cellular, animal, and computational approaches, creating a translational pipeline that connects metabolic regulation to disease biology and therapeutic optimization.